t cell subsets การใช้

• While attending Yale, Rothman studied T cell subsets in the lab of Dr . Leonard Chess at Columbia University.
• Th9 cells are claimed to be an IL9 ( interleukin 9 )  producing T cell subset focused on defending helminth infections.
• In particular, his research addressed whether the multiple immunological functions of T cells were invested in a single lineage or represented the specialized activities of distinct T cell subsets.
• Laboratory manifestations include progressive lymphopenia that primarily affects CD4 and CD8 T cell subsets, reduced B cell and / or NK cell counts in some patients, eosinophilia, and immunoglobulin abnormalities.
• Additionally, this integrin was much more common on CD8 + T cells activated in the Peyer's patches ( PP T-cells ) compared to other T cell subsets, such as peripheral and mesenteric lymph nodes activated T cells.
• He described the immunopathology of idiopathic demyelinating neuropathy showing T cell subsets, mononuclear cells and Human Leukocyte Antigen class I and II expression within nerve, demonstrating the possibility of an immunological role for Schwann cells, and challenging the dogma that nerve was an immunologically privileged site.
• For example, in a controlled study, 61 elderly volunteers, after 6 months of a daily dose of " L . bulgaricus ", responded to the intake of probiotic with an increase in the percentage of NK cells, an improvement in the parameters defining the immune risk profile ( IRP ), and an increase in the T cell subsets that are less differentiated.
• Like other'unconventional'T cell subsets bearing invariant TCRs, such as CD1d-restricted Natural Killer T cells, gamma delta T cells exhibit several characteristics that place them at the border between the more evolutionarily primitive innate immune system that permits a rapid beneficial response to a variety of foreign agents, and the adaptive immune system, where B and T cells coordinate a slower but highly antigen-specific immune response leading to long-lasting memory against subsequent challenges by the same antigen.